Although without seeing the plant “in person” or culturing tissue in a lab it’s impossible to say for sure, here are the most likely causes of the problem you see on this dracaena:
1. Fluoride toxicity. Dracaenas are very sensitive to too much fluoride, whether it’s in the water or in fertilizers that are high in phosphate, which has fluorine in it. Try removing the plant from the pot, gently take off some of the old soil and repot. In the future water with bottled/distilled water if your town adds fluoride to the water. Ask at your local garden center for a houseplant fertilizer that’s higher in nitrogen and lower in phosphates.
2. Leaf scorch from too bright light (direct sun) can cause leaf blotches. This is often combined with damage from low-humidity. These plants like bright light but not direct sun.
Be sure to let this plant dry out a bit in between watering, and check it to see if it’s root bound and needs a new pot.
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