This could be a viral disease, and/or a combination of issues. Virus diseases infect tomatoes and can cause leaves to curl, discolor, and/or develop mosaic patterns (which appears in your photo to be affecting the stem and leaves). Its hard to say from the photo, but it appears there may be white, powdery mildew on the plant? This is a fungal disease that affects tomatoes (and many other plants), but powdery mildew would not cause the stem mottling and leaf curl seen here. Additionally, environmental issues, like too much water in the soil around the roots can cause plant distortion from excess release of ethylene gas as a result of “drowning” roots.
We’ve included some links that may help you to narrow down the cause, but we also recommend that you get a local opinion from a Master Gardner group, home/farm advisor’s office, or a local garden center.
http://www.clemson.edu/extension/hgic/pests/plant_pests/veg_fruit/hgic2217.html
http://www.ipm.ucdavis.edu/PMG/GARDEN/VEGES/tomato.html
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